December 26th, 2019

Insect olfactory organ: the antenna

Mosquito OBP database (mOBPdb)

Welcome to the database for odorant binding proteins (OBP) for mosquitoes.

The molecular basis of the odorant perception of the mosquitoes is encoded by a series of proteins. One of the members considered very important in this process are the odorant binding proteins (OBPs) which are involved in the transport of hydrophobic odorants and pheromones to the odorant receptors (ORs) and have emerged as novel targets for repellants.

We are providing in this database, full genomic data (list of OBP genes, chromosomal or supercontig localization, sequence alignment data, phylogenetic data and orthologues) for 21 mosquito species, 18 coming from the Anophelinae group and 3 coming from the Culicinae group.

There are 3 genus that are covered in the database: Anopheles, Aedes and Culex.

There are 3 families of odorant binding proteins in mosquitoes :

  1. the Classic OBPs
  2. the PlusC OBPs
  3. the Two-domains also know as duplex and OBPs formerly know as the Atypical OBPs

The hallmark of OBPs are their conserved 6 cysteines that forms 3 disulphide bridges.However the number of cysteines and the disulphide connectivity patterns of the OBPs vary among the different subfamilies. Click here for a graphical illustration. A subgroup in the Classic OBPs called the MinusC OBPs and a subgroup in the two domain OBP subfamily called the matype2 do not have all the six conserved cysteines in their OBP domains. Atypical odorant binding proteins are in fact two-domain OBPs, where each domain is distantly related to the Classic OBPs.

We are also providing in this database

  • 3D structures for some Classic OBPs (from A. gambiae, C. quinquefasciatus, A. aegypti) obtained through comparative modelling in the form of downloadable PDB files.
  • functional characterization of these modeled Classic OBPs screened against a large library of 126 odorants known to be repellents and attractants using molecular docking technique together with corresponding free energies of binding (FEB), Ki values (i.e Kd), size-independant ligand binding efficiencies values and PDB files of corresponding protein-odorant complexes.

Results for 3D modelling and subsequent ligand screening is not yet available for the other Classic OBPs and also  PlusC and Two-domains (duplex formerly know as atypical) OBPs. We are currently working to make them available soon.

Visit the help page for more information

Please cite

Manoharan M, Ng Fuk Chong M, Vaïtinadapoulé A, Frumence E, Sowdhamini R, Offmann B. Comparative genomics of odorant binding proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus. Genome Biol Evol. 2013;5(1):163-80.

Contact details

Bernard Offmann (bernard.offmann ‘@’ univ-nantes.fr)

Developping team

Head: Bernard Offmann (University of Nantes, France), Sowdhamini Ramanathan (NCBS – TIFR, India)
Current students: Marine Averty, Nicolas Antunes, Bavikha Mam, Surbhi Dhingra
Former students: Malini Manoharan, Matthieu Ng Fuk Cheong, Aurore Vaïtinadapoullé, Etienne Frumence, Olivier Cadet, Charlotte Berthelier, Amandine Lecerf Defer.

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